Compound Detail
CHEMBL168371
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL168371 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BLHLYSLDSMMWFB-NWISIEMHSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
371.9
MW (Da)
4.70
ALogP
3
HBA
0
HBD
21.7
PSA (Ų)
0.76
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.29
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Rattus norvegicus CHEMBL376 | IC50 | 6.29 | 6.29 | 519.0 | 1 |
| Sodium-dependent dopamine transporter CHEMBL338 | IC50 | 6.12 | 6.12 | 750.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Rattus norvegicus | IC50 | = | 519.0 | nM | 6.29 | Ability to inhibit high-affinity uptake of [3H]DA into striatal nerve endings (s... | 11277529 |
| Sodium-dependent dopamine transporter | IC50 | = | 750.0 | nM | 6.12 | Ability to inhibit binding of [3H]WIN-35428 to dopamine transporter in rat cauda... | 11277529 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11277529 | 10.1016/s0960-894x(01)00068-3 | Sodium-dependent dopamine transporter | 1 |
| 11277529 | 10.1016/s0960-894x(01)00068-3 | Rattus norvegicus | 1 |
| 11277529 | 10.1016/s0960-894x(01)00068-3 | Sodium-dependent serotonin transporter | 1 |
Data from ChEMBL 36 via Core Engine