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Compound Detail

CHEMBL177765

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COc1ccc(CC(C)NCC(O)COc2ccc(-c3nc(-c4cccs4)c[nH]3)cc2)cc1OC

Basic Information

ChEMBL ID CHEMBL177765
Phase Preclinical
Structure Type MOL
InChI Key HYHBOCVMHLENOI-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

493.6
MW (Da)
4.78
ALogP
7
HBA
3
HBD
88.6
PSA (Ų)
0.26
QED
0
Ro5 Violations
12
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H31N3O4S
MW 493.63
Aromatic Rings 4
Heavy Atoms 35
NP-Likeness -0.80

Activity Summary

Kd 2 meas. best 8.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-1 adrenergic receptor
CHEMBL5471
Kd 8.22 8.22 6.0 1
Beta-2 adrenergic receptor
CHEMBL5414
Kd 4.91 4.91 12302.7 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
6134834 10.1021/jm00361a004 Beta-1 adrenergic receptor 1
6134834 10.1021/jm00361a004 Beta-2 adrenergic receptor 1
6134834 10.1021/jm00361a004 Adrenergic receptor beta; ADRB1 & ADRB2 1

Data from ChEMBL 36 via Core Engine