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Compound Detail

CHEMBL177860

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COc1ccc(CC(C)(C)NCC(O)COc2ccc(-c3nc(-c4cccs4)c[nH]3)cc2)cc1OC

Basic Information

ChEMBL ID CHEMBL177860
Phase Preclinical
Structure Type MOL
InChI Key GHOOLNQEESNSKW-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

507.7
MW (Da)
5.17
ALogP
7
HBA
3
HBD
88.6
PSA (Ų)
0.25
QED
2
Ro5 Violations
12
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C28H33N3O4S
MW 507.66
Aromatic Rings 4
Heavy Atoms 36
NP-Likeness -0.80

Activity Summary

Kd 2 meas. best 8.04

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-1 adrenergic receptor
CHEMBL5471
Kd 8.04 8.04 9.1 1
Beta-2 adrenergic receptor
CHEMBL5414
Kd 4.44 4.44 36307.8 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
6134834 10.1021/jm00361a004 Beta-1 adrenergic receptor 1
6134834 10.1021/jm00361a004 Beta-2 adrenergic receptor 1
6134834 10.1021/jm00361a004 Adrenergic receptor beta; ADRB1 & ADRB2 1

Data from ChEMBL 36 via Core Engine