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Compound Detail

CHEMBL179498

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COC(=O)C1C2CCC(CC1c1ccc(-c3ccsc3)cc1)N2

Basic Information

ChEMBL ID CHEMBL179498
Phase Preclinical
Structure Type MOL
InChI Key BFMOQGLGYMZXPC-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

327.4
MW (Da)
3.81
ALogP
4
HBA
1
HBD
38.3
PSA (Ų)
0.87
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H21NO2S
MW 327.45
Aromatic Rings 2
Heavy Atoms 23
NP-Likeness 0.11

Activity Summary

Ki 3 meas. best 9.64

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Sodium-dependent serotonin transporter
CHEMBL313
Ki 9.64 9.64 0.2 1
Sodium-dependent dopamine transporter
CHEMBL338
Ki 8.19 8.19 6.4 1
Norepinephrine transporter
CHEMBL304
Ki 7.41 7.41 39.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
15686927 10.1016/j.bmcl.2004.12.014 Sodium-dependent serotonin transporter 1
15686927 10.1016/j.bmcl.2004.12.014 Sodium-dependent dopamine transporter 1
15686927 10.1016/j.bmcl.2004.12.014 Norepinephrine transporter 1
15686927 10.1016/j.bmcl.2004.12.014 Monoamine transporters; serotonin & dopamine 1
15686927 10.1016/j.bmcl.2004.12.014 Monoamine transporters; Norepinephrine & serotonin 1

Data from ChEMBL 36 via Core Engine