Compound Detail
CHEMBL1863061
FLURTAMONE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL1863061 |
| Name | FLURTAMONE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NYRMIJKDBAQCHC-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
333.3
MW (Da)
3.93
ALogP
3
HBA
1
HBD
38.3
PSA (Ų)
0.92
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.33
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nicotiana tabacum CHEMBL613059 | IC50 | 7.33 | 7.33 | 47.0 | 1 |
| 15-cis-phytoene desaturase CHEMBL2366472 | IC50 | 6.7 | 6.7 | 199.5 | 1 |
| Trypanosoma cruzi CHEMBL368 | IC50 | 4.26 | 4.26 | 55500.0 | 1 |
| L6 CHEMBL614793 | IC50 | 4.08 | 4.08 | 82820.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Nicotiana tabacum | IC50 | = | 47.0 | nM | 7.33 | Inhibition of colored carotenoid formation in Nicotiana tabacum (tobacco) | - |
| 15-cis-phytoene desaturase | IC50 | = | 199.53 | nM | 6.7 | Inhibition of Synechococcus PCC 7942 phytoene desaturase expressed in Escherichi... | 12720390 |
| Trypanosoma cruzi | IC50 | = | 55500.0 | nM | 4.26 | DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Cl... | - |
| L6 | IC50 | = | 82820.0 | nM | 4.08 | DNDI: Cytotoxicity against L-6 rat myoblasts from skeletal muscle cells | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1584/jpestics.21.473 | Nicotiana tabacum | 2 |
| - | 10.6019/CHEMBL1862790 | Trypanosoma cruzi | 1 |
| - | 10.6019/CHEMBL1862790 | L6 | 1 |
| 12720390 | 10.1021/jf0262413 | Zeta-carotene desaturase, chloroplastic/chromoplastic | 1 |
| 12720390 | 10.1021/jf0262413 | 15-cis-phytoene desaturase | 1 |
Data from ChEMBL 36 via Core Engine