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Compound Detail

CHEMBL1923486

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N#Cc1ccc(Oc2cc(Cl)ccc2Cl)c(OCCn2ccc(=O)[nH]c2=O)c1

Basic Information

ChEMBL ID CHEMBL1923486
Phase Preclinical
Structure Type MOL
InChI Key WNWQNABXCODFKF-UHFFFAOYSA-N
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

418.2
MW (Da)
3.59
ALogP
6
HBA
1
HBD
97.1
PSA (Ų)
0.66
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H13Cl2N3O4
MW 418.24
Aromatic Rings 3
Heavy Atoms 28
NP-Likeness -1.49

Activity Summary

EC50 4 meas. best 7.37

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Human immunodeficiency virus 1
CHEMBL378
EC50 7.37 6.5825 43.0 4

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
22081993 10.1021/jm201134m Human immunodeficiency virus 1 4
22081993 10.1021/jm201134m MT2 2

Data from ChEMBL 36 via Core Engine