Assay Detail
Functional
CHEMBL1925636
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Antiviral activity against Human immunodeficiency virus 1 NL4.3 infected in human MT2 cells assessed as inhibition of viral infection
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Computationally-guided optimization of a docking hit to yield catechol diethers as potent anti-HIV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 8.19 | 10.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1923490 | — | — | 1 | 10.26 |
| CHEMBL1923492 | — | — | 1 | 9.49 |
| CHEMBL175691 | RILPIVIRINE | 4.0 | 1 | 9.17 |
| CHEMBL567204 | — | — | 1 | 9.00 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 9.00 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.70 |
| CHEMBL1923491 | — | — | 1 | 8.49 |
| CHEMBL1923489 | — | — | 1 | 8.30 |
| CHEMBL1923481 | — | — | 1 | 7.89 |
| CHEMBL1923480 | — | — | 1 | 7.85 |
| CHEMBL1923488 | — | — | 1 | 7.82 |
| CHEMBL1923482 | — | — | 1 | 7.77 |
| CHEMBL1923487 | — | — | 1 | 7.70 |
| CHEMBL1923493 | — | — | 1 | 7.70 |
| CHEMBL1923486 | — | — | 1 | 7.37 |
| CHEMBL1923477 | — | — | 1 | 7.05 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.96 |
| CHEMBL1923475 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1923490 | — | EC50 | = | 0.055 | nM | 10.26 |
| CHEMBL1923492 | — | EC50 | = | 0.32 | nM | 9.49 |
| CHEMBL175691 | RILPIVIRINE | EC50 | = | 0.67 | nM | 9.17 |
| CHEMBL567204 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1923491 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL1923489 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1923481 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1923480 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1923488 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1923482 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1923487 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1923493 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1923486 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1923477 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1923475 | — | EC50 | = | 140.0 | nM | 6.85 |