Compound Detail
CHEMBL1923489
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Basic Information
| ChEMBL ID | CHEMBL1923489 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AXHHDHSEUVTPBV-DUXPYHPUSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
409.8
MW (Da)
3.60
ALogP
6
HBA
1
HBD
97.1
PSA (Ų)
0.60
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human immunodeficiency virus 1 CHEMBL378 | EC50 | 8.3 | 7.2075 | 5.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Human immunodeficiency virus 1 | EC50 | = | 5.0 | nM | 8.3 | Antiviral activity against Human immunodeficiency virus 1 3B infected in human M... | 22081993 |
| Human immunodeficiency virus 1 | EC50 | = | 5.0 | nM | 8.3 | Antiviral activity against Human immunodeficiency virus 1 NL4.3 infected in huma... | 22081993 |
| Human immunodeficiency virus 1 | EC50 | = | 370.0 | nM | 6.43 | Antiviral activity against Human immunodeficiency virus 1 NL4.3 reverse transcri... | 22081993 |
| Human immunodeficiency virus 1 | EC50 | = | 1600.0 | nM | 5.8 | Antiviral activity against Human immunodeficiency virus 1 NL4.3 reverse transcri... | 22081993 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22081993 | 10.1021/jm201134m | Human immunodeficiency virus 1 | 4 |
| 22081993 | 10.1021/jm201134m | MT2 | 2 |
Data from ChEMBL 36 via Core Engine