Assay Detail
Functional
CHEMBL1925638
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Antiviral activity against Human immunodeficiency virus 1 NL4.3 reverse transcriptase K103N and Y181C double mutant infected in human MT2 cells assessed as inhibition of viral infection
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Computationally-guided optimization of a docking hit to yield catechol diethers as potent anti-HIV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 6.61 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL567204 | — | — | 1 | 9.00 |
| CHEMBL175691 | RILPIVIRINE | 4.0 | 1 | 8.70 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.30 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.52 |
| CHEMBL1923492 | — | — | 1 | 7.07 |
| CHEMBL1923490 | — | — | 1 | 6.66 |
| CHEMBL1923482 | — | — | 1 | 6.24 |
| CHEMBL1923491 | — | — | 1 | 6.05 |
| CHEMBL1923477 | — | — | 1 | 5.92 |
| CHEMBL1923489 | — | — | 1 | 5.80 |
| CHEMBL1923481 | — | — | 1 | 5.77 |
| CHEMBL1923480 | — | — | 1 | 5.77 |
| CHEMBL1923475 | — | — | 1 | 5.66 |
| CHEMBL1923486 | — | — | 1 | 5.55 |
| CHEMBL1923488 | — | — | 1 | 5.10 |
| CHEMBL1923487 | — | — | 1 | - |
| CHEMBL1923493 | — | — | 1 | - |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL567204 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL175691 | RILPIVIRINE | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1923492 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL1923490 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1923482 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL1923491 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1923477 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1923489 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1923481 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1923480 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1923475 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1923486 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1923488 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1923487 | — | EC50 | > | 43000.0 | nM | - |
| CHEMBL1923493 | — | EC50 | - | — | - | |
| CHEMBL57 | NEVIRAPINE | EC50 | > | 100000.0 | nM | - |