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Compound Detail

CHEMBL195418

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Cc1c(Cl)nc2ccccc2c1C(=O)NCCCCCCCNc1c2c(nc3ccccc13)CCCC2

Basic Information

ChEMBL ID CHEMBL195418
Phase Preclinical
Structure Type MOL
InChI Key VRNGRBIMQBSIJF-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

515.1
MW (Da)
7.42
ALogP
4
HBA
2
HBD
66.9
PSA (Ų)
0.17
QED
2
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C31H35ClN4O
MW 515.10
Aromatic Rings 4
Heavy Atoms 37
NP-Likeness -0.79

Activity Summary

IC50 2 meas. best 8.52

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Acetylcholinesterase
CHEMBL220
IC50 8.52 8.52 3.0 1
Cholinesterase
CHEMBL1914
IC50 7.5 7.5 32.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
15887964 10.1021/jm0493461 Acetylcholinesterase 1
15887964 10.1021/jm0493461 Cholinesterase 1

Data from ChEMBL 36 via Core Engine