Compound Detail
CHEMBL2023210
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CC(C)(C)N1C[C@@H](C(=O)N2CCC(c3ccnn3-c3ccc(F)c(Cl)c3)CC2)[C@H](c2ccc(F)cc2F)C1
Basic Information
| ChEMBL ID | CHEMBL2023210 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LNIHDGIRNYROME-XZOQPEGZSA-N |
3
Targets
5
Activities
2
Assay Types
6
PK Parameters
9
Publications
0
Known Names
Molecular Properties
545.0
MW (Da)
6.16
ALogP
4
HBA
0
HBD
41.4
PSA (Ų)
0.39
QED
2
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 9.3
IC50 2 meas. best 9.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Lysosomal Pro-X carboxypeptidase CHEMBL2335 | IC50 | 9.7 | 9.7 | 0.2 | 1 |
| Lysosomal Pro-X carboxypeptidase CHEMBL1255149 | IC50 | 9.52 | 9.52 | 0.3 | 1 |
| Mus musculus CHEMBL375 | Ki | 9.3 | 9.1 | 0.5 | 3 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 121.0 | mL.min-1.kg-1 | Mus musculus |
| F | 18.0 | % | Mus musculus |
| Fu | 0.18 | - | Homo sapiens |
| Fu | 0.16 | - | Mus musculus |
| T1/2 | 3.1 | hr | Mus musculus |
| Vd | 22.0 | L.kg-1 | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Lysosomal Pro-X carboxypeptidase | IC50 | = | 0.2 | nM | 9.7 | Inhibition of human PrCP | 22444683 |
| Lysosomal Pro-X carboxypeptidase | IC50 | = | 0.3 | nM | 9.52 | Inhibition of mouse PrCP | 22444683 |
| Mus musculus | Ki | = | 0.5 | nM | 9.3 | Ex-vivo inhibition of po dosed mouse PrCP in the absence of plasma by FRET analy... | 22444683 |
| Mus musculus | Ki | = | 0.7 | nM | 9.15 | Ex-vivo inhibition of PrCP in heat inactivated 25% plasma of po dosed mouse by F... | 22444683 |
| Mus musculus | Ki | = | 1.4 | nM | 8.85 | Ex-vivo inhibition of PrCP in heat inactivated 100% plasma of po dosed mouse by ... | 22444683 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22444683 | 10.1016/j.bmcl.2012.02.075 | Mus musculus | 13 |
| 22444683 | 10.1016/j.bmcl.2012.02.075 | Plasma | 4 |
| 22444683 | 10.1016/j.bmcl.2012.02.075 | Lysosomal Pro-X carboxypeptidase | 2 |
| 22444683 | 10.1016/j.bmcl.2012.02.075 | Brain | 2 |
| 22444683 | 10.1016/j.bmcl.2012.02.075 | Nucleic Acid | 2 |
| 22444683 | 10.1016/j.bmcl.2012.02.075 | ADMET | 2 |
| 22444683 | 10.1016/j.bmcl.2012.02.075 | Liver microsomes | 1 |
| 22444683 | 10.1016/j.bmcl.2012.02.075 | Liver | 1 |
| 22444683 | 10.1016/j.bmcl.2012.02.075 | LLC-PK1 | 1 |
Data from ChEMBL 36 via Core Engine