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Compound Detail

CHEMBL2096751

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COc1ccc(CCNC[C@H](O)COc2ccc(-c3ncc[nH]3)cc2)cc1OC

Basic Information

ChEMBL ID CHEMBL2096751
Phase Preclinical
Structure Type MOL
InChI Key BEZXHPWSRAUJBW-SFHVURJKSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

397.5
MW (Da)
2.67
ALogP
6
HBA
3
HBD
88.6
PSA (Ų)
0.43
QED
0
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H27N3O4
MW 397.48
Aromatic Rings 3
Heavy Atoms 29
NP-Likeness -0.62

Activity Summary

Kd 2 meas. best 7.68

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-1 adrenergic receptor
CHEMBL5471
Kd 7.68 7.68 20.9 1
Beta-2 adrenergic receptor
CHEMBL5414
Kd 4.53 4.53 29512.1 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
6134834 10.1021/jm00361a004 Beta-1 adrenergic receptor 1
6134834 10.1021/jm00361a004 Beta-2 adrenergic receptor 1
6134834 10.1021/jm00361a004 Adrenergic receptor beta; ADRB1 & ADRB2 1

Data from ChEMBL 36 via Core Engine