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Compound Detail

CHEMBL2105088

LOBENDAZOLE
🧪 Phase II
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🧪 Phase II
CCOC(=O)Nc1nc2ccccc2[nH]1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL2105088
Name LOBENDAZOLE
Phase Phase II
Structure Type MOL
InChI Key OKOVSTKGUBOSTB-UHFFFAOYSA-N

Known Names

Lobendazol Lobendazole NSC-42044 SK&F 24529 SK&F-24529
1
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
5
Known Names

Molecular Properties

205.2
MW (Da)
2.13
ALogP
3
HBA
2
HBD
67.0
PSA (Ų)
0.79
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral

Flags

Natural Product
USAN Stem -bendazole
USAN Year 1972

Extended Properties

Molecular Formula C10H11N3O2
MW 205.22
Aromatic Rings 2
Heavy Atoms 15
NP-Likeness -1.19

Activity Summary

IC50 5 meas. best 7.43

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Giardia intestinalis
CHEMBL612652
 IC50 7.43 6.89 37.0 5

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Giardia intestinalis IC50 = 37.0 nM 7.43 Giardicidal activity against Giardia intestinalis IMSS isolate incubated for 48 ... 33360795
Giardia intestinalis IC50 = 61.0 nM 7.21 Giardicidal activity against nitazoxanide-resistant Giardia intestinalis incubat... 33360795
Giardia intestinalis IC50 = 85.0 nM 7.07 Giardicidal activity against Giardia intestinalis WB ATCC 30957 incubated for 48... 33360795
Giardia intestinalis IC50 = 200.0 nM 6.7 Giardicidal activity against metronidazole-resistant Giardia intestinalis incuba... 33360795
Giardia intestinalis IC50 = 916.0 nM 6.04 Giardicidal activity against albendazole-resistant Giardia intestinalis incubate... 33360795

Literature References

PubMed DOI Target Context # Activities
33360795 10.1016/j.ejmech.2020.113110 Giardia intestinalis 7
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
- 10.6019/CHEMBL4651402 SARS-CoV-2 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
- 10.21203/rs.3.rs-23951/v1 SARS-CoV-2 1
- 10.6019/CHEMBL4495564 Replicase polyprotein 1ab 1

Data from ChEMBL 36 via Core Engine