Assay Detail
Functional
CHEMBL4820175
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Giardicidal activity against Giardia intestinalis IMSS isolate incubated for 48 hrs by hemocytometric counting method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Giardia intestinalis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The giardicidal activity of lobendazole, fabomotizole, tenatoprazole and ipriflavone: A ligand-based virtual screening and in vitro study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.35 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1401 | NITAZOXANIDE | 4.0 | 1 | 7.82 |
| CHEMBL1475252 | TENATOPRAZOLE | 2.0 | 1 | 7.70 |
| CHEMBL165790 | IPRIFLAVONE | 2.0 | 1 | 7.60 |
| CHEMBL3707307 | FABOMOTIZOLE | 3.0 | 1 | 7.54 |
| CHEMBL2105088 | LOBENDAZOLE | 2.0 | 1 | 7.43 |
| CHEMBL1483 | ALBENDAZOLE | 4.0 | 1 | 7.43 |
| CHEMBL137 | METRONIDAZOLE | 4.0 | 1 | 5.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1401 | NITAZOXANIDE | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1475252 | TENATOPRAZOLE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL165790 | IPRIFLAVONE | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3707307 | FABOMOTIZOLE | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2105088 | LOBENDAZOLE | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1483 | ALBENDAZOLE | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL137 | METRONIDAZOLE | IC50 | = | 1226.0 | nM | 5.91 |