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Compound Detail

CHEMBL3707307

FABOMOTIZOLE
🧪 Phase III
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🧪 Phase III
CCOc1ccc2nc(SCCN3CCOCC3)[nH]c2c1

Basic Information

ChEMBL ID CHEMBL3707307
Name FABOMOTIZOLE
Phase Phase III
Structure Type MOL
InChI Key WWNUCVSRRUDYPP-UHFFFAOYSA-N

Known Names

Afobazol Afobazole Aphobazole CM-346 Fabomotizol Fabomotizole Obenoxazine
1
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
7
Known Names
1
Indications

Molecular Properties

307.4
MW (Da)
2.39
ALogP
5
HBA
1
HBD
50.4
PSA (Ų)
0.83
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral

Extended Properties

Molecular Formula C15H21N3O2S
MW 307.42
Aromatic Rings 2
Heavy Atoms 21
NP-Likeness -2.28

Indications

Anxiety

ATC Classification

N05BX04
fabomotizole
Level 1: NERVOUS SYSTEM
Level 2: PSYCHOLEPTICS

Activity Summary

IC50 5 meas. best 7.54

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Giardia intestinalis
CHEMBL612652
IC50 7.54 7.368 29.0 5

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
33360795 10.1016/j.ejmech.2020.113110 Giardia intestinalis 5
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
- 10.21203/rs.3.rs-23951/v1 SARS-CoV-2 1
- 10.1101/2020.04.21.054387 SARS-CoV-2 1
- 10.6019/CHEMBL4495564 Replicase polyprotein 1ab 1

Data from ChEMBL 36 via Core Engine