Assay Detail
Functional
CHEMBL4820177
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Giardicidal activity against nitazoxanide-resistant Giardia intestinalis incubated for 48 hrs by hemocytometric counting method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Giardia intestinalis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The giardicidal activity of lobendazole, fabomotizole, tenatoprazole and ipriflavone: A ligand-based virtual screening and in vitro study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.82 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL165790 | IPRIFLAVONE | 2.0 | 1 | 7.85 |
| CHEMBL1475252 | TENATOPRAZOLE | 2.0 | 1 | 7.31 |
| CHEMBL2105088 | LOBENDAZOLE | 2.0 | 1 | 7.21 |
| CHEMBL3707307 | FABOMOTIZOLE | 3.0 | 1 | 7.19 |
| CHEMBL1483 | ALBENDAZOLE | 4.0 | 1 | 6.56 |
| CHEMBL137 | METRONIDAZOLE | 4.0 | 1 | 5.91 |
| CHEMBL1401 | NITAZOXANIDE | 4.0 | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL165790 | IPRIFLAVONE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1475252 | TENATOPRAZOLE | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL2105088 | LOBENDAZOLE | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL3707307 | FABOMOTIZOLE | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1483 | ALBENDAZOLE | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL137 | METRONIDAZOLE | IC50 | = | 1221.0 | nM | 5.91 |
| CHEMBL1401 | NITAZOXANIDE | IC50 | = | 1973.0 | nM | 5.71 |