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Compound Detail

CHEMBL2111606

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COc1cccc(OC)c1OCCNC[C@H]1C(=O)c2ccccc2O[C@@H]1c1ccccc1

Basic Information

ChEMBL ID CHEMBL2111606
Phase Preclinical
Structure Type MOL
InChI Key PUAAUDBUJSSOLX-NBGIEHNGSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

433.5
MW (Da)
4.31
ALogP
6
HBA
1
HBD
66.0
PSA (Ų)
0.51
QED
0
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H27NO5
MW 433.50
Aromatic Rings 3
Heavy Atoms 32
NP-Likeness 0.49

Activity Summary

Kd 2 meas. best 8.27

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor alpha-1
CHEMBL1907610
Kd 8.27 8.27 5.4 1
Adrenergic receptor alpha-2
CHEMBL2093864
Kd 4.85 4.85 14125.4 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1977906 10.1021/jm00173a004 Adrenergic receptor alpha-1 1
1977906 10.1021/jm00173a004 Adrenergic receptor alpha-2 1
1977906 10.1021/jm00173a004 Unchecked 1

Data from ChEMBL 36 via Core Engine