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Compound Detail

CHEMBL2113550

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CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NC(=O)Nc4ccc(NS(=O)(=O)c5ncccn5)cc4)ncnc32)[C@H](O)[C@@H]1O

Basic Information

ChEMBL ID CHEMBL2113550
Phase Preclinical
Structure Type MOL
InChI Key RLAHFLODROYPNU-GRXQJBFDSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

584.6
MW (Da)
-0.18
ALogP
13
HBA
6
HBD
235.5
PSA (Ų)
0.15
QED
3
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H24N10O7S
MW 584.58
Aromatic Rings 4
Heavy Atoms 41
NP-Likeness -0.64

Activity Summary

Ki 3 meas. best 7.78

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A2a
CHEMBL302
Ki 7.78 7.78 16.8 1
Adenosine receptor A3
CHEMBL3360
Ki 6.39 6.39 405.0 1
Adenosine receptor A1
CHEMBL318
Ki 6.14 6.14 725.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9703463 10.1021/jm980147p Adenosine receptor A1 1
9703463 10.1021/jm980147p Adenosine receptor A2a 1
9703463 10.1021/jm980147p Adenosine receptor A3 1
9703463 10.1021/jm980147p Adenosine receptors; A1 & A3 1
9703463 10.1021/jm980147p Adenosine receptor A2a and A3 1

Data from ChEMBL 36 via Core Engine