Compound Detail
CHEMBL213661
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Basic Information
| ChEMBL ID | CHEMBL213661 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NKARZGURZMIRMA-RBSFLKMASA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
265.4
MW (Da)
0.27
ALogP
4
HBA
3
HBD
63.9
PSA (Ų)
0.71
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.08
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glycogen phosphorylase, muscle form CHEMBL4696 | IC50 | 6.08 | 6.08 | 840.0 | 1 |
| Glycogen phosphorylase, liver form CHEMBL2568 | IC50 | 6.07 | 6.07 | 850.0 | 1 |
| Glycogen phosphorylase, liver form CHEMBL3239 | IC50 | 5.91 | 5.91 | 1220.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glycogen phosphorylase, muscle form | IC50 | = | 840.0 | nM | 6.08 | Inhibition of non-phosphorylated form of rabbit muscle glycogen phosphorylase | 16970395 |
| Glycogen phosphorylase, liver form | IC50 | = | 850.0 | nM | 6.07 | Inhibition of phosphorylated form of pig liver glycogen phosphorylase | 16970395 |
| Glycogen phosphorylase, liver form | IC50 | = | 1220.0 | nM | 5.91 | Inhibition of phosphorylated form of rat liver glycogen phosphorylase | 16970395 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16970395 | 10.1021/jm060496g | Glycogen phosphorylase, muscle form | 2 |
| 16970395 | 10.1021/jm060496g | Glycogen phosphorylase, liver form | 2 |
Data from ChEMBL 36 via Core Engine