Compound Detail
CHEMBL222419
GSK-237701A Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL222419 |
| Name | GSK-237701A |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UHCHLTQBLNUYRT-GFCCVEGCSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
457.9
MW (Da)
5.00
ALogP
7
HBA
1
HBD
88.6
PSA (Ų)
0.42
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 9.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase PLK1 CHEMBL3024 | IC50 | 9.1 | 9.1 | 0.8 | 1 |
| Serine/threonine-protein kinase PLK3 CHEMBL4897 | IC50 | 8.22 | 8.22 | 6.0 | 1 |
| HCT-116 CHEMBL394 | IC50 | 7.6 | 7.6 | 25.0 | 1 |
| Cyclin-dependent kinase 2 CHEMBL301 | IC50 | 5.8 | 5.8 | 1584.9 | 1 |
| Inhibitor of nuclear factor kappa-B kinase subunit epsilon CHEMBL3529 | IC50 | 4.7 | 4.7 | 19952.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase PLK1 | IC50 | = | 0.8 | nM | 9.1 | Inhibition of human PLK1 kinase domain expressed in baculovirus-infected Trichop... | 19237286 |
| Serine/threonine-protein kinase PLK3 | IC50 | = | 6.0 | nM | 8.22 | Inhibition of full length human PLK3 expressed in baculovirus-infected Trichoplu... | 19237286 |
| HCT-116 | IC50 | = | 25.0 | nM | 7.6 | Antiproliferative activity against human HCT116 cells after 72 hrs by luminescen... | 19237286 |
| Cyclin-dependent kinase 2 | IC50 | = | 1584.89 | nM | 5.8 | Inhibition of CDK2 | 16997559 |
| Inhibitor of nuclear factor kappa-B kinase subunit epsilon | IC50 | = | 19952.62 | nM | 4.7 | Inhibition of human recombinant IKKepsilon by TR-FRET assay | 16997559 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase ABL1 | 14 |
| - | 10.6019/CHEMBL1961873 | Epidermal growth factor receptor | 10 |
| - | 10.6019/CHEMBL1961873 | Platelet-derived growth factor receptor alpha | 8 |
| - | 10.6019/CHEMBL1961873 | Mast/stem cell growth factor receptor Kit | 8 |
| - | 10.6019/CHEMBL1961873 | Proto-oncogene tyrosine-protein kinase receptor Ret | 6 |
| - | 10.6019/CHEMBL1961873 | Cyclin-dependent kinase 2 | 4 |
| - | 10.6019/CHEMBL1961873 | Leucine-rich repeat serine/threonine-protein kinase 2 | 4 |
| - | 10.6019/CHEMBL1961873 | Protein kinase C beta type | 4 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase B-raf | 4 |
| - | 10.6019/CHEMBL1961873 | Receptor-type tyrosine-protein kinase FLT3 | 4 |
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase Lyn | 4 |
| - | 10.6019/CHEMBL2007661 | Serine/threonine-protein kinase TBK1 | 2 |
| - | 10.6019/CHEMBL1961873 | Ribosomal protein S6 kinase alpha-4 | 2 |
| - | 10.6019/CHEMBL1961873 | Ribosomal protein S6 kinase alpha-5 | 2 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase MRCK beta | 2 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase MRCK alpha | 2 |
| - | 10.6019/CHEMBL1961873 | Rhodopsin kinase GRK7 | 2 |
| - | 10.6019/CHEMBL1961873 | G protein-coupled receptor kinase 6 | 2 |
| - | 10.6019/CHEMBL1961873 | RAC-alpha serine/threonine-protein kinase | 2 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase D3 | 2 |
Data from ChEMBL 36 via Core Engine