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Compound Detail

CHEMBL2337633

MYCALOLIDE B
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COC[C@@H](OC)C(=O)O[C@H](CC[C@H](C)[C@@H](C[C@@H]1OC(=O)C[C@@H](O)C/C=C/C(=O)[C@H](C)[C@H](OC)c2coc(n2)-c2coc(n2)-c2coc(n2)/C=C/C[C@H](OC)[C@H]1C)OC)[C@H](C)[C@H](OC(C)=O)[C@H](C)/C=C/N(C)C=O

Basic Information

ChEMBL ID CHEMBL2337633
Name MYCALOLIDE B
Phase Preclinical
Structure Type MOL
InChI Key ZYDMLFOHENLMIN-IEUMCZPDSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

1027.2
MW (Da)

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C52H74N4O17
MW 1027.17

Activity Summary

IC50 3 meas. best 8.33

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
HL-60
CHEMBL383
IC50 8.33 8.33 4.7 1
NON-PROTEIN TARGET
CHEMBL3879801
IC50 7.28 7.28 52.0 1
Unchecked
CHEMBL612545
IC50 5.77 5.77 1700.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23357626 10.1016/j.bmcl.2012.12.052 HL-60 4
23357626 10.1016/j.bmcl.2012.12.052 NON-PROTEIN TARGET 3
23357626 10.1016/j.bmcl.2012.12.052 Unchecked 1
23357626 10.1016/j.bmcl.2012.12.052 HeLa S3 1

Data from ChEMBL 36 via Core Engine