Compound Detail
CHEMBL2387337
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C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1.Cl
Basic Information
| ChEMBL ID | CHEMBL2387337 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NBIFFUUTIJLCTP-LJSWWFPMSA-N |
| Parent Compound | CHEMBL214022 |
| Active Moiety | CHEMBL214022 |
4
Targets
6
Activities
3
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
790.0
MW (Da)
2.86
ALogP
8
HBA
6
HBD
186.2
PSA (Ų)
0.08
QED
2
Ro5 Violations
19
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.22
IC50 2 meas. best 7.48
Ki 2 meas. best 9.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mu-type opioid receptor CHEMBL270 | Ki | 9.05 | 9.05 | 0.9 | 1 |
| Delta-type opioid receptor CHEMBL236 | Ki | 8.96 | 8.96 | 1.1 | 1 |
| Delta-type opioid receptor CHEMBL3222 | IC50 | 7.48 | 7.48 | 33.0 | 1 |
| Delta-type opioid receptor CHEMBL236 | EC50 | 7.22 | 7.22 | 60.0 | 1 |
| Mu-type opioid receptor CHEMBL270 | EC50 | 7.22 | 7.22 | 60.0 | 1 |
| Mu-type opioid receptor CHEMBL4354 | IC50 | 6.96 | 6.96 | 110.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mu-type opioid receptor | Ki | = | 0.9 | nM | 9.05 | Displacement of [3H]DAMGO from rat mu opioid receptor expressed in mouse HN9.10 ... | 23623418 |
| Delta-type opioid receptor | Ki | = | 1.1 | nM | 8.96 | Displacement of [3H]DPDPE from human delta opioid receptor expressed in mouse HN... | 23623418 |
| Delta-type opioid receptor | IC50 | = | 33.0 | nM | 7.48 | Inhibition of delta opioid receptor in mouse vas deferens assessed as inhibition... | 23623418 |
| Mu-type opioid receptor | EC50 | = | 60.0 | nM | 7.22 | Agonist activity at rat mu opioid receptor expressed in CHO cells by [35S]GTP-ga... | 23623418 |
| Delta-type opioid receptor | EC50 | = | 60.0 | nM | 7.22 | Agonist activity at human delta opioid receptor expressed in CHO cells by [35S]G... | 23623418 |
| Mu-type opioid receptor | IC50 | = | 110.0 | nM | 6.96 | Inhibition of mu opioid receptor in guinea pig ileum/longitudinal muscle with my... | 23623418 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23623418 | 10.1016/j.bmcl.2013.03.065 | Delta-type opioid receptor | 4 |
| 23623418 | 10.1016/j.bmcl.2013.03.065 | Mu-type opioid receptor | 4 |
Data from ChEMBL 36 via Core Engine