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Compound Detail

CHEMBL252171

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Cc1cc(C)n(-c2cc(NC(=O)CN3CCN(C)CC3)nc(-c3ccco3)n2)n1

Basic Information

ChEMBL ID CHEMBL252171
Phase Preclinical
Structure Type MOL
InChI Key BWVAXODRSJSHDC-UHFFFAOYSA-N
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

395.5
MW (Da)
1.73
ALogP
8
HBA
1
HBD
92.3
PSA (Ų)
0.70
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H25N7O2
MW 395.47
Aromatic Rings 3
Heavy Atoms 29
NP-Likeness -2.67

Activity Summary

Ki 5 meas. best 8.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A2a
CHEMBL251
Ki 8.7 8.7 2.0 2
Adenosine receptor A2a
CHEMBL302
Ki 7.85 7.85 14.0 1
Adenosine receptor A1
CHEMBL226
Ki 5.77 5.765 1700.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18189346 10.1021/jm070623o Adenosine receptor A2a 2
18189346 10.1021/jm070623o Adenosine receptor A1 1
18189346 10.1021/jm070623o Unchecked 1
18189346 10.1021/jm070623o Rattus norvegicus 1
18307292 10.1021/jm701185v Adenosine receptor A2a 1
18307292 10.1021/jm701185v Adenosine receptor A1 1
18307292 10.1021/jm701185v Unchecked 1
21966889 10.1021/jm200956q Rattus norvegicus 1

Data from ChEMBL 36 via Core Engine