Compound Detail
CHEMBL268445
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Basic Information
| ChEMBL ID | CHEMBL268445 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MZJRATHCEWAQPC-UHFFFAOYSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
358.8
MW (Da)
2.00
ALogP
9
HBA
1
HBD
107.4
PSA (Ų)
0.56
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.76
Ki 1 meas. best 6.06
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | Ki | 6.06 | 6.06 | 870.0 | 1 |
| Mus musculus CHEMBL375 | IC50 | 5.76 | 5.76 | 1750.0 | 1 |
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 4.04 | 4.04 | 91000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | Ki | = | 870.0 | nM | 6.06 | Displacement of [3H]AMPA from Ionotropic glutamate receptor AMPA in rat cortical... | 11855983 |
| Mus musculus | IC50 | = | 1750.0 | nM | 5.76 | Concentration that inhibits by 50% depolarization induced by 5M AMPA | 11855983 |
| Glutamate NMDA receptor | IC50 | = | 91000.0 | nM | 4.04 | Inhibition of stimulated [3H](+)-MK-801 binding to N-methyl-D-aspartate glutamat... | 11855983 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11855983 | 10.1021/jm010995b | Mus musculus | 2 |
| 11855983 | 10.1021/jm010995b | Glutamate receptor ionotropic, NMDA 1 | 1 |
| 11855983 | 10.1021/jm010995b | Glutamate receptor ionotropic, AMPA | 1 |
| 11855983 | 10.1021/jm010995b | Glutamate receptor ionotropic, kainate | 1 |
| 11855983 | 10.1021/jm010995b | Glutamate NMDA receptor | 1 |
Data from ChEMBL 36 via Core Engine