Compound Detail
CHEMBL27065
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Basic Information
| ChEMBL ID | CHEMBL27065 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZEOXLCVRBAOHIV-UHFFFAOYSA-N |
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
302.4
MW (Da)
3.25
ALogP
4
HBA
1
HBD
72.2
PSA (Ų)
0.81
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 6.36
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Endothelin-1 receptor CHEMBL252 | IC50 | 6.36 | 5.53 | 440.0 | 2 |
| Endothelin-1 receptor CHEMBL4566 | IC50 | 5.51 | 5.105 | 3100.0 | 2 |
| Endothelin receptor type B CHEMBL1785 | IC50 | 4.31 | 4.31 | 49000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Endothelin-1 receptor | IC50 | = | 440.0 | nM | 6.36 | Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membra... | - |
| Endothelin-1 receptor | IC50 | = | 3100.0 | nM | 5.51 | Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoraci... | 7861414 |
| Endothelin-1 receptor | IC50 | = | 20000.0 | nM | 4.7 | Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smo... | 7731020 |
| Endothelin-1 receptor | IC50 | = | 20000.0 | nM | 4.7 | Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells | 8308857 |
| Endothelin receptor type B | IC50 | = | 49000.0 | nM | 4.31 | Binding affinity against human ETB receptor in transfected COS 7 cell membrane p... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/0960-894X(96)00441-6 | Endothelin-1 receptor | 1 |
| - | 10.1016/0960-894X(96)00441-6 | Endothelin receptor type B | 1 |
| 7861414 | 10.1021/jm00004a012 | Endothelin-1 receptor | 1 |
| 7731020 | 10.1021/jm00008a013 | Endothelin-1 receptor | 1 |
| 8308857 | 10.1021/jm00029a001 | Endothelin-1 receptor | 1 |
Data from ChEMBL 36 via Core Engine