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Compound Detail

CHEMBL284808

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CCOC(=O)CCCNCC(O)COc1ccccc1

Basic Information

ChEMBL ID CHEMBL284808
Phase Preclinical
Structure Type MOL
InChI Key KDYQAVKVKSEKLG-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

281.4
MW (Da)
1.36
ALogP
5
HBA
2
HBD
67.8
PSA (Ų)
0.50
QED
0
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H23NO4
MW 281.35
Aromatic Rings 1
Heavy Atoms 20
NP-Likeness -0.54

Activity Summary

Kd 2 meas. best 6.6

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-1 adrenergic receptor
CHEMBL5471
Kd 6.6 6.6 251.2 1
Beta-2 adrenergic receptor
CHEMBL5414
Kd 6.0 6.0 1000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
6130153 10.1021/jm00354a002 Beta-1 adrenergic receptor 2
6130153 10.1021/jm00354a002 Beta-2 adrenergic receptor 1
6130153 10.1021/jm00354a002 Molecular identity unknown 1

Data from ChEMBL 36 via Core Engine