Assay Detail
Binding
CHEMBL650921
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In vitro ability to block beta-1 adrenergic receptor in guinea pig right atria.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Ultra-short-acting beta-adrenergic receptor blocking agents. 1. (Aryloxy)propanolamines containing esters in the nitrogen substituent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 32 | 6.81 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287651 | — | — | 1 | 8.70 |
| CHEMBL31021 | — | — | 1 | 8.60 |
| CHEMBL31529 | — | — | 1 | 8.50 |
| CHEMBL31811 | — | — | 1 | 8.00 |
| CHEMBL32902 | — | — | 1 | 7.80 |
| CHEMBL283289 | — | — | 1 | 7.50 |
| CHEMBL31938 | — | — | 1 | 7.50 |
| CHEMBL31857 | — | — | 1 | 7.40 |
| CHEMBL287242 | — | — | 1 | 7.40 |
| CHEMBL30942 | — | — | 1 | 7.40 |
| CHEMBL416030 | — | — | 1 | 7.40 |
| CHEMBL31772 | — | — | 1 | 7.30 |
| CHEMBL448775 | — | — | 1 | 7.10 |
| CHEMBL287452 | — | — | 1 | 7.00 |
| CHEMBL281109 | — | — | 1 | 6.90 |
| CHEMBL418770 | — | — | 1 | 6.90 |
| CHEMBL31568 | — | — | 1 | 6.70 |
| CHEMBL31591 | — | — | 1 | 6.60 |
| CHEMBL284808 | — | — | 1 | 6.60 |
| CHEMBL31888 | — | — | 1 | 6.50 |
| CHEMBL31411 | — | — | 1 | 6.40 |
| CHEMBL32736 | — | — | 1 | 6.40 |
| CHEMBL31099 | — | — | 1 | 6.20 |
| CHEMBL31611 | — | — | 1 | 6.20 |
| CHEMBL31508 | — | — | 1 | 5.90 |
| CHEMBL282537 | — | — | 1 | 5.90 |
| CHEMBL288546 | — | — | 1 | 5.80 |
| CHEMBL31392 | — | — | 1 | 5.70 |
| CHEMBL30538 | — | — | 1 | 5.70 |
| CHEMBL31598 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287651 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL31021 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL31529 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL31811 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL32902 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL283289 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL31938 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL31857 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL287242 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL30942 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL416030 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL31772 | — | Kd | = | 50.12 | nM | 7.30 |
| CHEMBL448775 | — | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL287452 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL418770 | — | Kd | = | 125.89 | nM | 6.90 |
| CHEMBL281109 | — | Kd | = | 125.89 | nM | 6.90 |
| CHEMBL31568 | — | Kd | = | 199.53 | nM | 6.70 |
| CHEMBL31591 | — | Kd | = | 251.19 | nM | 6.60 |
| CHEMBL284808 | — | Kd | = | 251.19 | nM | 6.60 |
| CHEMBL31888 | — | Kd | = | 316.23 | nM | 6.50 |
| CHEMBL31411 | — | Kd | = | 398.11 | nM | 6.40 |
| CHEMBL32736 | — | Kd | = | 398.11 | nM | 6.40 |
| CHEMBL31099 | — | Kd | = | 630.96 | nM | 6.20 |
| CHEMBL31611 | — | Kd | = | 630.96 | nM | 6.20 |
| CHEMBL31508 | — | Kd | = | 1258.93 | nM | 5.90 |
| CHEMBL282537 | — | Kd | = | 1258.93 | nM | 5.90 |
| CHEMBL288546 | — | Kd | = | 1584.89 | nM | 5.80 |
| CHEMBL31392 | — | Kd | = | 1995.26 | nM | 5.70 |
| CHEMBL30538 | — | Kd | = | 1995.26 | nM | 5.70 |
| CHEMBL31598 | — | Kd | = | 3162.28 | nM | 5.50 |
| CHEMBL285958 | — | Kd | = | 6309.57 | nM | 5.20 |
| CHEMBL32514 | — | Kd | = | 7943.28 | nM | 5.10 |