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Compound Detail

CHEMBL32902

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CCOC(=O)CCCCNCC(O)COc1ccccc1C

Basic Information

ChEMBL ID CHEMBL32902
Phase Preclinical
Structure Type MOL
InChI Key XRBQYEOKDOQJNX-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

309.4
MW (Da)
2.06
ALogP
5
HBA
2
HBD
67.8
PSA (Ų)
0.48
QED
0
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C17H27NO4
MW 309.41
Aromatic Rings 1
Heavy Atoms 22
NP-Likeness -0.52

Activity Summary

Kd 2 meas. best 7.8

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-1 adrenergic receptor
CHEMBL5471
Kd 7.8 7.8 15.8 1
Beta-2 adrenergic receptor
CHEMBL5414
Kd 7.4 7.4 39.8 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
6130153 10.1021/jm00354a002 Beta-1 adrenergic receptor 2
6130153 10.1021/jm00354a002 Beta-2 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine