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Compound Detail

CHEMBL288546

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CCOC(=O)CCNCC(O)COc1ccc(OC)cc1

Basic Information

ChEMBL ID CHEMBL288546
Phase Preclinical
Structure Type MOL
InChI Key ASCJYWNNUNMICY-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

297.4
MW (Da)
0.98
ALogP
6
HBA
2
HBD
77.0
PSA (Ų)
0.50
QED
0
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H23NO5
MW 297.35
Aromatic Rings 1
Heavy Atoms 21
NP-Likeness -0.57

Activity Summary

Kd 2 meas. best 5.8

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-1 adrenergic receptor
CHEMBL5471
Kd 5.8 5.8 1584.9 1
Beta-2 adrenergic receptor
CHEMBL5414
Kd 4.9 4.9 12589.2 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
6130153 10.1021/jm00354a002 Beta-1 adrenergic receptor 1
6130153 10.1021/jm00354a002 Beta-2 adrenergic receptor 1
6130153 10.1021/jm00354a002 Molecular identity unknown 1

Data from ChEMBL 36 via Core Engine