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Compound Detail

CHEMBL31772

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CCOC(=O)CCNCC(O)COc1ccccc1

Basic Information

ChEMBL ID CHEMBL31772
Phase Preclinical
Structure Type MOL
InChI Key BGDSCKIMCCCOPQ-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

267.3
MW (Da)
0.97
ALogP
5
HBA
2
HBD
67.8
PSA (Ų)
0.52
QED
0
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C14H21NO4
MW 267.32
Aromatic Rings 1
Heavy Atoms 19
NP-Likeness -0.72

Activity Summary

Kd 2 meas. best 7.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-1 adrenergic receptor
CHEMBL5471
Kd 7.3 7.3 50.1 1
Beta-2 adrenergic receptor
CHEMBL5414
Kd 5.9 5.9 1258.9 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
6130153 10.1021/jm00354a002 Beta-1 adrenergic receptor 2
6130153 10.1021/jm00354a002 Beta-2 adrenergic receptor 1
6130153 10.1021/jm00354a002 Molecular identity unknown 1

Data from ChEMBL 36 via Core Engine