Compound Detail
CHEMBL303428
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CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(Oc2ccccc2OC)c(OCCOC(=O)Nc2ccccn2)n1
Basic Information
| ChEMBL ID | CHEMBL303428 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZYPQETRCACBJNS-UHFFFAOYSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
635.7
MW (Da)
6.35
ALogP
10
HBA
2
HBD
150.9
PSA (Ų)
0.16
QED
2
Ro5 Violations
13
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.05
Kd 1 meas. best 7.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Endothelin-1 receptor CHEMBL252 | IC50 | 8.05 | 8.05 | 9.0 | 1 |
| Endothelin-1 receptor CHEMBL4566 | Kd | 7.9 | 7.9 | 12.6 | 1 |
| Endothelin receptor type B CHEMBL1785 | IC50 | 7.2 | 7.2 | 63.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Endothelin-1 receptor | IC50 | = | 9.0 | nM | 8.05 | Receptor binding affinity was determined against [125I]ET1 with recombinant huma... | - |
| Endothelin-1 receptor | Kd | = | 12.59 | nM | 7.9 | Evaluation for functional inhibitory potency prevention of ET-1 induced constric... | - |
| Endothelin receptor type B | IC50 | = | 63.0 | nM | 7.2 | Receptor binding affinity was determined against [125I]ET1 with membranes prepar... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(97)00400-9 | Endothelin-1 receptor | 2 |
| - | 10.1016/S0960-894X(97)00400-9 | Endothelin receptor type B | 1 |
Data from ChEMBL 36 via Core Engine