Compound Detail
CHEMBL313046
PILOSININE Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL313046 |
| Name | PILOSININE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YOIFSTUAGLOWPB-SSDOTTSWSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
180.2
MW (Da)
0.53
ALogP
4
HBA
0
HBD
44.1
PSA (Ų)
0.62
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.54
EC50 1 meas. best 4.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor CHEMBL1907609 | IC50 | 5.54 | 5.54 | 2890.0 | 1 |
| Muscarinic acetylcholine receptor M1 CHEMBL276 | IC50 | 5.0 | 5.0 | 10000.0 | 1 |
| Muscarinic acetylcholine receptor M5 CHEMBL2035 | EC50 | 4.58 | 4.58 | 26302.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor | IC50 | = | 2890.0 | nM | 5.54 | Ability to displace [3H]cis--2-methyl-5-((dimethylamino)methyl)-1,3-di oxolane f... | 1732522 |
| Muscarinic acetylcholine receptor M1 | IC50 | = | 10000.0 | nM | 5.0 | Ability to displace [3H]pirenzepine (pir) from muscarinic acetylcholine receptor... | 1732522 |
| Muscarinic acetylcholine receptor M5 | EC50 | = | 26302.68 | nM | 4.58 | Partial agonist activity at N-terminal FLAG tagged/C-terminal NanoLuc tagged hum... | 37042802 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1732522 | 10.1021/jm00079a002 | Muscarinic acetylcholine receptor M1 | 3 |
| 1732522 | 10.1021/jm00079a002 | Muscarinic acetylcholine receptor | 2 |
| 37042802 | 10.1021/acs.jnatprod.2c01079 | Muscarinic acetylcholine receptor M1 | 2 |
| 37042802 | 10.1021/acs.jnatprod.2c01079 | Muscarinic acetylcholine receptor M5 | 2 |
| 1732522 | 10.1021/jm00079a002 | Muscarinic acetylcholine receptor M3 | 1 |
| 37042802 | 10.1021/acs.jnatprod.2c01079 | Muscarinic acetylcholine receptor M2 | 1 |
| 37042802 | 10.1021/acs.jnatprod.2c01079 | Muscarinic acetylcholine receptor M3 | 1 |
| 37042802 | 10.1021/acs.jnatprod.2c01079 | Muscarinic acetylcholine receptor M4 | 1 |
Data from ChEMBL 36 via Core Engine