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Compound Detail

CHEMBL316309

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CC[C@H]1C(O)SC[C@@H]1Cc1cncn1C

Basic Information

ChEMBL ID CHEMBL316309
Phase Preclinical
Structure Type MOL
InChI Key GYARYICIOJNOLJ-OZRKRLJNSA-N
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

226.3
MW (Da)
1.67
ALogP
4
HBA
1
HBD
38.0
PSA (Ų)
0.85
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C11H18N2OS
MW 226.34
Aromatic Rings 1
Heavy Atoms 15
NP-Likeness 0.55

Activity Summary

IC50 2 meas. best 6.54
Kd 1 meas. best 5.6

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M1
CHEMBL276
IC50 6.54 6.54 285.0 1
Muscarinic acetylcholine receptor
CHEMBL1907609
IC50 6.48 6.48 330.0 1
Muscarinic acetylcholine receptor M2
CHEMBL309
Kd 5.6 5.6 2511.9 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1732522 10.1021/jm00079a002 Muscarinic acetylcholine receptor M1 4
1732522 10.1021/jm00079a002 Muscarinic acetylcholine receptor 2
1732522 10.1021/jm00079a002 Muscarinic acetylcholine receptor M3 1
1732522 10.1021/jm00079a002 Muscarinic acetylcholine receptor M2 1

Data from ChEMBL 36 via Core Engine