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Compound Detail

CHEMBL3222055

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Nc1nc(-c2ccco2)nc2sc(CN3CCOCC3)cc12

Basic Information

ChEMBL ID CHEMBL3222055
Phase Preclinical
Structure Type MOL
InChI Key WKCYYQAUFYIEID-UHFFFAOYSA-N
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

316.4
MW (Da)
2.37
ALogP
7
HBA
1
HBD
77.4
PSA (Ų)
0.80
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H16N4O2S
MW 316.39
Aromatic Rings 3
Heavy Atoms 22
NP-Likeness -2.21

Activity Summary

Ki 4 meas. best 7.54

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A2a
CHEMBL251
Ki 7.54 7.54 29.0 2
Adenosine receptor A1
CHEMBL226
Ki 5.78 5.78 1680.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1039/C1MD00082A Mus musculus 1
- 10.1039/C1MD00082A Adenosine receptor A2a 1
- 10.1039/C1MD00082A Adenosine receptor A1 1
24164628 10.1021/jm4011669 Adenosine receptor A2b 1
24164628 10.1021/jm4011669 Adenosine receptor A2a 1
24164628 10.1021/jm4011669 Adenosine receptor A3 1
24164628 10.1021/jm4011669 Adenosine receptor A1 1
24164628 10.1021/jm4011669 Mus musculus 1

Data from ChEMBL 36 via Core Engine