Compound Detail
CHEMBL322378
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Basic Information
| ChEMBL ID | CHEMBL322378 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UYQFMKJXWOUBBI-GWQXNCQPSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
390.5
MW (Da)
4.82
ALogP
3
HBA
1
HBD
49.4
PSA (Ų)
0.74
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M1 CHEMBL276 | IC50 | 8.1 | 8.1 | 8.0 | 1 |
| Muscarinic acetylcholine receptor M3 CHEMBL320 | IC50 | 5.89 | 5.89 | 1300.0 | 1 |
| Muscarinic acetylcholine receptor M2 CHEMBL309 | IC50 | 5.62 | 5.62 | 2400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M1 | IC50 | = | 8.0 | nM | 8.1 | Displacement of [3H]pirenzepine binding to muscarinic M1 receptor in brain corte... | 10571170 |
| Muscarinic acetylcholine receptor M3 | IC50 | = | 1300.0 | nM | 5.89 | Displacement of [3H]methylscopolamine binding to muscarinic M3 receptor in subma... | 10571170 |
| Muscarinic acetylcholine receptor M2 | IC50 | = | 2400.0 | nM | 5.62 | Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat h... | 10571170 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10571170 | 10.1016/s0960-894x(99)00528-4 | Muscarinic acetylcholine receptor M1 | 1 |
| 10571170 | 10.1016/s0960-894x(99)00528-4 | Muscarinic acetylcholine receptor M2 | 1 |
| 10571170 | 10.1016/s0960-894x(99)00528-4 | Muscarinic acetylcholine receptor M3 | 1 |
Data from ChEMBL 36 via Core Engine