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Compound Detail

CHEMBL3290991

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CCOc1ccc(Nc2ccc(CCNCC(O)c3ccc(O)c(CO)c3)cc2)cc1

Basic Information

ChEMBL ID CHEMBL3290991
Phase Preclinical
Structure Type MOL
InChI Key FYXBZOFYWHUPHB-UHFFFAOYSA-N
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

422.5
MW (Da)
3.89
ALogP
6
HBA
5
HBD
94.0
PSA (Ų)
0.30
QED
0
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H30N2O4
MW 422.53
Aromatic Rings 3
Heavy Atoms 31
NP-Likeness -0.20

Activity Summary

EC50 2 meas. best 8.9
Ki 2 meas. best 6.8

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 8.9 8.9 1.3 1
Beta-2 adrenergic receptor
CHEMBL210
Ki 6.8 6.8 158.5 1
Beta-2 adrenergic receptor
CHEMBL5414
EC50 6.7 6.7 199.5 1
Beta-1 adrenergic receptor
CHEMBL213
Ki 4.5 4.5 31622.8 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
24813741 10.1016/j.bmcl.2014.04.069 Beta-2 adrenergic receptor 3
24813741 10.1016/j.bmcl.2014.04.069 Beta-1 adrenergic receptor 1
24813741 10.1016/j.bmcl.2014.04.069 Unchecked 1

Data from ChEMBL 36 via Core Engine