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Compound Detail

CHEMBL3652006

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Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1[C@H]1C[C@@H](N)C[C@@H](C(F)(F)F)C1

Basic Information

ChEMBL ID CHEMBL3652006
Phase Preclinical
Structure Type MOL
InChI Key FAHDUHMZUVZGJA-HZSPNIEDSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

491.5
MW (Da)
5.03
ALogP
5
HBA
3
HBD
106.9
PSA (Ų)
0.44
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H22F5N5O
MW 491.46
Aromatic Rings 3
Heavy Atoms 35
NP-Likeness -0.85

Activity Summary

IC50 3 meas. best 9.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Serine/threonine-protein kinase pim-1
CHEMBL2147
IC50 9.0 9.0 1.0 1
Serine/threonine-protein kinase pim-2
CHEMBL4523
IC50 9.0 9.0 1.0 1
Serine/threonine-protein kinase pim-3
CHEMBL5407
IC50 9.0 9.0 1.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine