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Compound Detail

CHEMBL366389

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COc1ccc(CCNCC(O)COc2ccc(-c3nc(C(F)(F)F)c[nH]3)cc2)cc1OC

Basic Information

ChEMBL ID CHEMBL366389
Phase Preclinical
Structure Type MOL
InChI Key BPDMHTWYCOENTL-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

465.5
MW (Da)
3.68
ALogP
6
HBA
3
HBD
88.6
PSA (Ų)
0.37
QED
0
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H26F3N3O4
MW 465.47
Aromatic Rings 3
Heavy Atoms 33
NP-Likeness -0.61

Activity Summary

Kd 2 meas. best 8.27

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-1 adrenergic receptor
CHEMBL5471
Kd 8.27 8.27 5.4 1
Beta-2 adrenergic receptor
CHEMBL5414
Kd 5.89 5.89 1288.2 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
6134834 10.1021/jm00361a004 Beta-1 adrenergic receptor 1
6134834 10.1021/jm00361a004 Beta-2 adrenergic receptor 1
6134834 10.1021/jm00361a004 Adrenergic receptor beta; ADRB1 & ADRB2 1

Data from ChEMBL 36 via Core Engine