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Compound Detail

CHEMBL374302

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O=C(NN1C(=O)[C@@H]2C3C=CC(C4CC43)[C@@H]2C1=O)c1cccc(Br)c1

Basic Information

ChEMBL ID CHEMBL374302
Phase Preclinical
Structure Type MOL
InChI Key IYWDNVOMIGEONH-ADPPZMDZSA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

387.2
MW (Da)
2.15
ALogP
3
HBA
1
HBD
66.5
PSA (Ų)
0.62
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H15BrN2O3
MW 387.23
Aromatic Rings 1
Heavy Atoms 24
NP-Likeness -0.67

Activity Summary

EC50 3 meas. best 7.52

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cowpox virus
CHEMBL612672
EC50 7.52 6.87 30.0 2
Vaccinia virus
CHEMBL613493
EC50 7.3 7.3 50.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
17335190 10.1021/jm061484y Cowpox virus 2
17335190 10.1021/jm061484y Vaccinia virus 1
17335190 10.1021/jm061484y ADMET 1

Data from ChEMBL 36 via Core Engine