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Assay Detail

CHEMBL918573

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against CDV-resistant cowpox virus by CPE assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cowpox virus
Confidence 1 — Organism
Curated By Intermediate

Target

Cowpox virus (CHEMBL612672)
Type ORGANISM
Organism Cowpox virus

Publication

N-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6- ethenocycloprop[f]isoindol-2-(1H)-yl)carboxamides: Identification of novel orthopoxvirus egress inhibitors.
Bailey TR, Rippin SR, Opsitnick E, Burns CJ, Pevear DC, Collett MS, Rhodes G, Tohan S, Huggins JW, Baker RO, Kern ER, Keith KA, Dai D, Yang G, Hruby D, Jordan R.
J Med Chem (2007) 50 : 1442 -1444
PubMed 17335190 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 17 6.29 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL375768 1 7.70
CHEMBL374302 1 7.52
CHEMBL221054 1 7.16
CHEMBL220610 1 7.00
CHEMBL223485 1 7.00
CHEMBL220150 1 5.75
CHEMBL373719 1 5.51
CHEMBL374020 1 5.46
CHEMBL219691 1 5.40
CHEMBL375998 1 5.34
CHEMBL373720 1 5.33
CHEMBL219690 1 -
CHEMBL375755 1 -
CHEMBL374301 1 -
CHEMBL222674 1 -
CHEMBL220098 1 -
CHEMBL376645 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL375768 EC50 = 20.0 nM 7.70
CHEMBL374302 EC50 = 30.0 nM 7.52
CHEMBL221054 EC50 = 70.0 nM 7.16
CHEMBL220610 EC50 = 100.0 nM 7.00
CHEMBL223485 EC50 = 100.0 nM 7.00
CHEMBL220150 EC50 = 1800.0 nM 5.75
CHEMBL373719 EC50 = 3100.0 nM 5.51
CHEMBL374020 EC50 = 3500.0 nM 5.46
CHEMBL219691 EC50 = 4000.0 nM 5.40
CHEMBL375998 EC50 = 4600.0 nM 5.34
CHEMBL373720 EC50 = 4700.0 nM 5.33
CHEMBL219690 EC50 - -
CHEMBL375755 EC50 - -
CHEMBL374301 EC50 - -
CHEMBL222674 EC50 > 5000.0 nM -
CHEMBL220098 EC50 > 20000.0 nM -
CHEMBL376645 EC50 > 50000.0 nM -