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Compound Detail

CHEMBL3752583

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C[C@H]1[C@H](C)CC[C@]2(C(=O)N(C)O)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@H]12

Basic Information

ChEMBL ID CHEMBL3752583
Phase Preclinical
Structure Type MOL
InChI Key XRKTXJSNHVZOFY-QHQGJMPNSA-N
7
Targets
7
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

485.8
MW (Da)
6.85
ALogP
3
HBA
2
HBD
60.8
PSA (Ų)
0.24
QED
1
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C31H51NO3
MW 485.75
Aromatic Rings 0
Heavy Atoms 35
NP-Likeness 2.70

Activity Summary

EC50 7 meas. best 5.35

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
A2780
CHEMBL614004
EC50 5.35 5.35 4500.0 1
A549
CHEMBL392
EC50 5.01 5.01 9700.0 1
ADMET
CHEMBL612558
EC50 5.0 5.0 10100.0 1
HT-29
CHEMBL384
EC50 4.91 4.91 12300.0 1
NON-PROTEIN TARGET
CHEMBL3879801
EC50 4.9 4.9 12500.0 1
FaDu
CHEMBL612250
EC50 4.82 4.82 15100.0 1
MCF7
CHEMBL387
EC50 4.81 4.81 15400.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine