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Compound Detail

CHEMBL38634

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c1ccc(CN2CCC3(CCc4ccccc4O3)CC2)cc1

Basic Information

ChEMBL ID CHEMBL38634
Phase Preclinical
Structure Type MOL
InChI Key CRKWADRIYCMTBU-UHFFFAOYSA-N
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
12
Publications
0
Known Names

Molecular Properties

293.4
MW (Da)
4.05
ALogP
2
HBA
0
HBD
12.5
PSA (Ų)
0.83
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H23NO
MW 293.41
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness -0.41

Activity Summary

Ki 4 meas. best 9.21

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Sigma non-opioid intracellular receptor 1
CHEMBL287
Ki 9.21 9.21 0.6 2
Unchecked
CHEMBL612545
Ki 7.66 7.66 21.9 1
Sigma 2 receptor
CHEMBL613288
Ki 7.66 7.66 22.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20067271 10.1021/jm901542q Unchecked 3
9572880 10.1021/jm970740r Sigma non-opioid intracellular receptor 1 2
9572880 10.1021/jm970740r Sigma 2 receptor 1
9572880 10.1021/jm970740r Serotonin 2 (5-HT2) receptor 1
9572880 10.1021/jm970740r D(2) dopamine receptor 1
9572880 10.1021/jm970740r Alpha-1A adrenergic receptor 1
9572880 10.1021/jm970740r Alpha-1B adrenergic receptor 1
9572880 10.1021/jm970740r Muscarinic acetylcholine receptor M2 1
9572880 10.1021/jm970740r Muscarinic acetylcholine receptor M3 1
9572880 10.1021/jm970740r Opioid receptor 1
9572880 10.1021/jm970740r Glutamate receptor ionotropic, NMDA 2C 1
20067271 10.1021/jm901542q Sigma non-opioid intracellular receptor 1 1

Data from ChEMBL 36 via Core Engine