Assay Detail
Binding
CHEMBL802065
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its binding affinity towards sigma 1 receptor using [3H](+)-pentazocine from guinea pig brain
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
1'-Benzyl-3,4-dihydrospiro[2H-1- benzothiopyran-2,4'-piperidine] (spipethiane), a potent and highly selective sigma1 ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.03 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39900 | SPIPETHIANE | — | 1 | 9.30 |
| CHEMBL38634 | — | — | 1 | 9.21 |
| CHEMBL41830 | — | — | 1 | 8.85 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.49 |
| CHEMBL38904 | — | — | 1 | 7.70 |
| CHEMBL38085 | — | — | 1 | 7.60 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39900 | SPIPETHIANE | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL38634 | — | Ki | = | 0.62 | nM | 9.21 |
| CHEMBL41830 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL38904 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL38085 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL42 | CLOZAPINE | Ki | = | 8500.0 | nM | 5.07 |