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Compound Detail

CHEMBL41830

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O=C1c2ccccc2CCC12CCN(Cc1ccccc1)CC2

Basic Information

ChEMBL ID CHEMBL41830
Phase Preclinical
Structure Type MOL
InChI Key PZWPPSAANHYITK-UHFFFAOYSA-N
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names

Molecular Properties

305.4
MW (Da)
4.10
ALogP
2
HBA
0
HBD
20.3
PSA (Ų)
0.83
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H23NO
MW 305.42
Aromatic Rings 2
Heavy Atoms 23
NP-Likeness -0.45

Activity Summary

Ki 5 meas. best 8.85

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Sigma non-opioid intracellular receptor 1
CHEMBL287
Ki 8.85 8.85 1.4 1
Sigma 2 receptor
CHEMBL613288
Ki 8.0 8.0 10.0 1
Serotonin 2 (5-HT2) receptor
CHEMBL2095200
Ki 6.66 6.66 218.0 1
Muscarinic acetylcholine receptor M2
CHEMBL309
Ki 5.57 5.57 2700.0 1
D(2) dopamine receptor
CHEMBL339
Ki 5.26 5.26 5500.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9572880 10.1021/jm970740r Sigma non-opioid intracellular receptor 1 2
9572880 10.1021/jm970740r Sigma 2 receptor 1
9572880 10.1021/jm970740r Serotonin 2 (5-HT2) receptor 1
9572880 10.1021/jm970740r D(2) dopamine receptor 1
9572880 10.1021/jm970740r Alpha-1A adrenergic receptor 1
9572880 10.1021/jm970740r Alpha-1B adrenergic receptor 1
9572880 10.1021/jm970740r Muscarinic acetylcholine receptor M2 1
9572880 10.1021/jm970740r Muscarinic acetylcholine receptor M3 1
9572880 10.1021/jm970740r Opioid receptor 1
9572880 10.1021/jm970740r Glutamate receptor ionotropic, NMDA 2C 1

Data from ChEMBL 36 via Core Engine