Assay Detail
Binding
CHEMBL744907
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Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M2 (CHEMBL309) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
1'-Benzyl-3,4-dihydrospiro[2H-1- benzothiopyran-2,4'-piperidine] (spipethiane), a potent and highly selective sigma1 ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.12 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27673 | METHOCTRAMINE | — | 1 | 7.82 |
| CHEMBL41830 | — | — | 1 | 5.57 |
| CHEMBL39900 | SPIPETHIANE | — | 1 | 4.97 |
| CHEMBL38904 | — | — | 1 | - |
| CHEMBL38634 | — | — | 1 | - |
| CHEMBL38085 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27673 | METHOCTRAMINE | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL41830 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL39900 | SPIPETHIANE | Ki | = | 10800.0 | nM | 4.97 |
| CHEMBL38904 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL38634 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL38085 | — | Ki | > | 10000.0 | nM | - |