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Compound Detail

CHEMBL3896115

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N#Cc1c[nH]c2nc(N)cc(-c3ccccc3)c12

Basic Information

ChEMBL ID CHEMBL3896115
Phase Preclinical
Structure Type MOL
InChI Key QMJRKPFSSQENNG-UHFFFAOYSA-N
1
Targets
8
Activities
3
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

234.3
MW (Da)
2.68
ALogP
3
HBA
2
HBD
78.5
PSA (Ų)
0.68
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C14H10N4
MW 234.26
Aromatic Rings 3
Heavy Atoms 18
NP-Likeness -0.40

Activity Summary

IC50 4 meas. best 6.85
EC50 2 meas. best 6.67
Ki 2 meas. best 8.52

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Leucine-rich repeat serine/threonine-protein kinase 2
CHEMBL1075104
Ki 8.52 8.22 3.0 2
Leucine-rich repeat serine/threonine-protein kinase 2
CHEMBL1075104
IC50 6.85 6.7225 140.0 4
Leucine-rich repeat serine/threonine-protein kinase 2
CHEMBL1075104
EC50 6.67 6.645 216.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
29023112 10.1021/acs.jmedchem.7b01186 Leucine-rich repeat serine/threonine-protein kinase 2 4

Data from ChEMBL 36 via Core Engine