Compound Detail
CHEMBL3928607
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Basic Information
| ChEMBL ID | CHEMBL3928607 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BHEBICBPOTVZFO-UHFFFAOYSA-N |
1
Targets
8
Activities
3
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
225.3
MW (Da)
3.16
ALogP
3
HBA
1
HBD
52.5
PSA (Ų)
0.69
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 6.07
EC50 2 meas. best 6.07
Ki 2 meas. best 7.51
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Leucine-rich repeat serine/threonine-protein kinase 2 CHEMBL1075104 | Ki | 7.51 | 7.365 | 31.0 | 2 |
| Leucine-rich repeat serine/threonine-protein kinase 2 CHEMBL1075104 | EC50 | 6.07 | 5.98 | 851.0 | 2 |
| Leucine-rich repeat serine/threonine-protein kinase 2 CHEMBL1075104 | IC50 | 6.07 | 5.9775 | 851.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29023112 | 10.1021/acs.jmedchem.7b01186 | Leucine-rich repeat serine/threonine-protein kinase 2 | 4 |
Data from ChEMBL 36 via Core Engine