Compound Detail
CHEMBL3982806
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CC1(O)CN(C(=O)N2CC=C(c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)cc(F)c7C6=O)c5CO)ccnc4[nH]3)CC2)C1
Basic Information
| ChEMBL ID | CHEMBL3982806 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OJNINYKJMHYTKF-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
637.7
MW (Da)
5.05
ALogP
6
HBA
3
HBD
122.2
PSA (Ų)
0.28
QED
2
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase BTK CHEMBL5251 | IC50 | 9.0 | 8.98 | 1.0 | 2 |
| Tyrosine-protein kinase BTK CHEMBL3259478 | IC50 | 7.83 | 7.83 | 14.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase BTK | IC50 | = | 1.0 | nM | 9.0 | Recombinant Human BTK Inhibition Assay: The inhibition assays were performed usi... | - |
| Tyrosine-protein kinase BTK | IC50 | = | 1.1 | nM | 8.96 | Inhibition of recombinant human full length BTK preincubated for 10 mins followe... | 28279528 |
| Tyrosine-protein kinase BTK | IC50 | = | 14.7 | nM | 7.83 | Inhibition of C57BL/6J mouse BTK assessed as decrease in anti-mouse IgM antibody... | 28279528 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28279528 | 10.1016/j.bmcl.2017.02.026 | ADMET | 3 |
| 28279528 | 10.1016/j.bmcl.2017.02.026 | Tyrosine-protein kinase BTK | 2 |
Data from ChEMBL 36 via Core Engine