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Compound Detail

CHEMBL4065457

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O=[N+]([O-])c1cncs1

Basic Information

ChEMBL ID CHEMBL4065457
Phase Preclinical
Structure Type MOL
InChI Key VVVCJCRUFSIVHI-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

130.1
MW (Da)
1.05
ALogP
4
HBA
0
HBD
56.0
PSA (Ų)
0.42
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C3H2N2O2S
MW 130.13
Aromatic Rings 1
Heavy Atoms 8
NP-Likeness -2.16

Activity Summary

IC50 2 meas. best 4.53

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Giardia intestinalis
CHEMBL612652
IC50 4.53 4.53 29571.0 1
Trichomonas vaginalis
CHEMBL612884
IC50 4.28 4.28 52859.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
28645659 10.1016/j.bmcl.2017.05.071 Giardia intestinalis 1
28645659 10.1016/j.bmcl.2017.05.071 Trichomonas vaginalis 1
28645659 10.1016/j.bmcl.2017.05.071 Leishmania amazonensis 1
28645659 10.1016/j.bmcl.2017.05.071 Leishmania mexicana 1
28645659 10.1016/j.bmcl.2017.05.071 Trypanosoma cruzi 1
28645659 10.1016/j.bmcl.2017.05.071 Vero 1

Data from ChEMBL 36 via Core Engine