Assay Detail
Functional
CHEMBL4056310
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Antiprotozoal activity against Giardia intestinalis IMSS:0696:1 (genotype A) trophozoites incubated for 48 hrs
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Giardia intestinalis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, in vitro and in vivo giardicidal activity of nitrothiazole-NSAID chimeras displaying broad antiprotozoal spectrum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.84 | 6.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4084390 | — | — | 1 | 6.84 |
| CHEMBL4100836 | — | — | 1 | 6.83 |
| CHEMBL4062705 | — | — | 1 | 6.76 |
| CHEMBL4092145 | — | — | 1 | 6.66 |
| CHEMBL4071348 | — | — | 1 | 6.64 |
| CHEMBL1401 | NITAZOXANIDE | 4.0 | 1 | 5.92 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 5.39 |
| CHEMBL137 | METRONIDAZOLE | 4.0 | 1 | 5.27 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 4.70 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 4.65 |
| CHEMBL4065457 | — | — | 1 | 4.53 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4084390 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL4100836 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL4062705 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL4092145 | — | IC50 | = | 221.0 | nM | 6.66 |
| CHEMBL4071348 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL1401 | NITAZOXANIDE | IC50 | = | 1214.0 | nM | 5.92 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 4079.0 | nM | 5.39 |
| CHEMBL137 | METRONIDAZOLE | IC50 | = | 5360.0 | nM | 5.27 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 22580.0 | nM | 4.65 |
| CHEMBL4065457 | — | IC50 | = | 29571.0 | nM | 4.53 |
| CHEMBL290960 | NIFURTIMOX | IC50 | - | — | - |